Significant improvement of bone marrow-derived MSC expansion from MDS patients by defined xeno-free medium

Abstract Background Robust and reliable in vitro and in vivo models of primary cells are necessary to study the pathomechanisms of Myelodysplastic Neoplasms (MDS) and identify novel therapeutic strategies. MDS-derived hematopoietic stem and progenitor cells (HSPCs) are reliant on the support of bone...

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Principais autores:	Eva Altrock, Carla Sens-Albert, Franziska Hofmann, Vladimir Riabov, Nanni Schmitt, Qingyu Xu, Johann-Christoph Jann, Felicitas Rapp, Laurenz Steiner, Alexander Streuer, Verena Nowak, Julia Obländer, Nadine Weimer, Iris Palme, Melda Göl, Ali Darwich, Patrick Wuchter, Georgia Metzgeroth, Mohamad Jawhar, Wolf-Karsten Hofmann, Daniel Nowak
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2023-06-01
Series:	Stem Cell Research & Therapy
Assuntos:	Bone marrow-derived mesenchymal stromal cells Myelodysplastic Neoplasms Xeno-free expansion
Acceso en liña:	https://doi.org/10.1186/s13287-023-03386-5
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