Prokaryotic organelle mitochondria drive tumorigenesis: “the original sin”

Mitochondria preserve bacterial traits because of their endosymbiotic origin, and their alterations in cancer cells reflect these prokaryotic-like traits. One such trait is the Warburg effect, wherein tumor cells rely primarily on aerobic glycolysis instead of oxidative phosphorylation. Cancer cells...

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Hlavní autoři:	Chaoyi Wang, Ming Luo, Jinhui Zhou, Qihao Zhang, Xiawei Ji, Jiayao He, Lingfei Wang, Yingpeng Huang, Xiangyang Xue, Fangyan Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-01-01
Edice:	Frontiers in Oncology
Témata:	mitochondria cancer endosymbiosis theory Warburg effect TCA cycle
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1632702/full
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