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Activating p53Y220C with a mutant-specific small molecule

Abstract TP53 is the most commonly mutated gene in cancer, but it remains recalcitrant to clinically meaningful therapeutic reactivation. We present here the discovery and characterization of a small molecule chemical inducer of proximity that activates mutant p53. We named this compound TRanscripti...

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Main Authors: Xijun Zhu, Woong Sub Byun, Dominika Ewa Pieńkowska, Kha The Nguyen, Mengxiong Wang, Sabin A. Nettles, Sai Gourisankar, Nick A. Phillips, Jan Gerhartz, Qixiang Geng, Tian Qiu, Jianing Zhong, Zixuan Jiang, Roman C. Sarott, Stephen M. Hinshaw, Tinghu Zhang, Laura D. Attardi, Radosław P. Nowak, Nathanael S. Gray
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2026-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-026-72165-6
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