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The kinase PDK1 is critical for promoting T follicular helper cell differentiation

The kinase PDK1 is a crucial regulator for immune cell development by connecting PI3K to downstream AKT signaling. However, the roles of PDK1 in CD4+ T cell differentiation, especially in T follicular helper (Tfh) cell, remain obscure. Here we reported PDK1 intrinsically promotes the Tfh cell differ...

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Principais autores: Zhen Sun, Yingpeng Yao, Menghao You, Jingjing Liu, Wenhui Guo, Zhihong Qi, Zhao Wang, Fang Wang, Weiping Yuan, Shuyang Yu
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2021-02-01
coleção:eLife
Assuntos:
PDK1
Tfh
Tcf-1
T follicular helper cell
differentiation
Acesso em linha:https://elifesciences.org/articles/61406
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