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DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme

Cholesterol synthesis occurs in the ER (endoplasmic reticulum), where most of the cholesterogenic machinery resides. As membrane-bound proteins, their topology is difficult to determine, and thus their structures are largely unknown. To help resolve this, we focused on the final enzyme in cholestero...

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Principais autores: Eser J. Zerenturk, Laura J. Sharpe, Andrew J. Brown
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press 2014-03-01
Series:Bioscience Reports
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Acceso en liña:http://www.bioscirep.org/bsr/034/e098/bsr034e098.htm
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