Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis

Abstract Crb2 is a cell polarity-related type I transmembrane protein expressed in the apical membrane of podocytes. Knockdown of crb2 causes glomerular permeability defects in zebrafish, and its complete knockout causes embryonic lethality in mice. There are also reports of Crb2 mutations in patien...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Akiko Tanoue, Kan Katayama, Yugo Ito, Kensuke Joh, Masaaki Toda, Taro Yasuma, Corina N. D’Alessandro-Gabazza, Hiroshi Kawachi, Kunimasa Yan, Masaaki Ito, Esteban C. Gabazza, Karl Tryggvason, Kaoru Dohi
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2021-10-01
Serier:	Scientific Reports
Online adgang:	https://doi.org/10.1038/s41598-021-00159-z
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!