A Dual‐Locking G‐Quadruplex DNA Targeting Strategy Based on a Tumor‐Accumulating Porphyrin‐Ruthenium(II) Conjugate for Type I Photodynamic Therapy

ABSTRACT The hypoxic tumor microenvironment severely limits the effectiveness of photodynamic therapy (PDT) in hepatocellular carcinoma (HCC). To overcome this limitation, we designed and synthesized a dual‐functional photosensitizer, PorRu, by conjugating a porphyrin unit with a ruthenium(II) polyp...

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Auteurs principaux:	Qiong Wu, Wan‐Wan Hong, Jia‐Hui Shi, Ren‐Shan Deng, Wan‐Qi Chen, Chan‐Ling Yuan, Wen‐Jie Mei
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2026-01-01
Collection:	Aggregate
Sujets:	"Dual‐Lock" binding G‐quadruplex DNA oxidative stress porphyrin‐ruthenium(II) conjugate pyroptosis Type I PDT photosensitizer
Accès en ligne:	https://doi.org/10.1002/agt2.70239
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