Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia

Abstract Frontotemporal dementia is characterized by progressive atrophy of frontal and/or temporal cortices at an early age of onset. The disorder shows considerable clinical, pathological, and genetic heterogeneity. Here we investigated the proteomic signatures of frontal and temporal cortex from...

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Detalhes bibliográficos

Principais autores:	Suzanne S. M. Miedema, Merel O. Mol, Frank T. W. Koopmans, David C. Hondius, Pim van Nierop, Kevin Menden, Christina F. de Veij Mestdagh, Jeroen van Rooij, Andrea B. Ganz, Iryna Paliukhovich, Shamiram Melhem, Ka Wan Li, Henne Holstege, Patrizia Rizzu, Ronald E. van Kesteren, John C. van Swieten, Peter Heutink, August B. Smit
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-07-01
Colecção:	Acta Neuropathologica Communications
Assuntos:	Frontotemporal dementia GRN MAPT Human brain proteomics Cell type enrichment
Acesso em linha:	https://doi.org/10.1186/s40478-022-01387-8
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