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A cautionary note on genomic complexity and bioinformatic analysis in cancer

Variant calling in complex genomic regions remains a critical challenge in cancer genomics, yet systematic evaluations of false positive rates in such regions are rarely reported. This investigative study examined somatic mutations in esophageal squamous cell carcinoma (ESCC) using Whole Genome Sequ...

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Furkejuvvon:
Váldodahkkit: Victoria A. Patten, Hocine Bendou, Denver T. Hendricks, Christopher G. Mathew, Wenlong Carl Chen, Joanna C. Fowler, Roshan K. Sood, Philip H. Jones, M. Iqbal Parker
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2025-12-01
Ráidu:Aspects of Molecular Medicine
Fáttát:
Bioinformatics
Next generation sequencing
Gene complexity
Somatic mutations
Variant callers
Cancer
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S2949688825000358
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