Hybrids of <i>Cinchona</i> Alkaloids and Bile Acids as Antiparasitic Agents Against <i>Trypanosoma cruzi</i>

The current chemotherapy of Chagas disease needs to be urgently improved. With this aim, a series of 16 hybrids of <i>Cinchona</i> alkaloids and bile acids were prepared by functionalization at position C-2 of the quinoline nucleus by a radical attack of a norcholane substituent via a Barton&#8722;Z...

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Autors principals:	Daniel Musikant, Aurélie Leverrier, Diana Bernal, Gabriel Ferri, Jorge A. Palermo, Martin M. Edreira
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2019-08-01
Col·lecció:	Molecules
Matèries:	<i>Cinchona</i> alkaloids bile acids hybrids <i>Trypanosoma cruzi</i> amastigotes antiparasitic activity
Accés en línia:	https://www.mdpi.com/1420-3049/24/17/3168
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