A comprehensive functional atlas of ALK kinase domain variants reveals resistance landscape to ALK inhibitors

Abstract Background ALK gene fusions are key oncogenic drivers in cancers such as non-small cell lung cancer, where they define a molecular subtype responsive to ALK tyrosine kinase inhibitors (TKIs). However, resistance commonly arises due to single nucleotide variants (SNVs) within the ALK tyrosin...

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Principais autores:	Hyeong-Cheol Oh, Yeonseung Han, Yoojin Chang, Hyongbum Henry Kim
格式:	Artigo
语言:	Inglês
出版:	BMC 2026-02-01
丛编:	Genome Biology
主题:	ALK fusion variants Prime editing screening Variants of uncertain significance
在线阅读:	https://doi.org/10.1186/s13059-026-03977-4
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