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A novel nomogram based on DNA damage response-related gene expression in patients with O-6-methylguanine-DNA methyltransferase unmethylated glioblastoma receiving temozolomide chemotherapy: A population-based analysis

Background and Aim: Glioblastoma (GBM) is the most lethal primary brain tumor. Patients with unmethylated O-6-methylguanine-DNA methyltransferase (MGMT) promoter have higher MGMT expression, are less sensitive to temozolomide (TMZ), and are linked to poor prognosis. The aim of this study was to iden...

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Principais autores: Rong Wang, Yingpeng Peng, Wei Wei, Yuling Zhou, Xiaonan Li, Yunfei Xia, Zhigang Liu
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Medknow Publications 2022-01-01
coleção:Glioma
Assuntos:
bioinformatics
dna damage response-related genes
glioblastoma
o-6-methylguanine-dna methyltransferase
nomogram
overall survival
prognostic model
temozolomide chemotherapy
Acesso em linha:http://www.jglioma.com/article.asp?issn=2589-6113;year=2022;volume=5;issue=1;spage=20;epage=28;aulast=Wang
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