Mutations of tyrosine 467 in the human norepinephrine transporter attenuate HIV-1 Tat-induced inhibition of dopamine transport while retaining physiological function.

Dysregulation of dopaminergic transmission induced by the HIV-1 transactivator of transcription (Tat) has been implicated as a central factor in the development of HIV-1 associated neurocognitive disorders (HAND). We have demonstrated that the tyrosine470 residue of the human dopamine transporter (h...

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Bibliografski detalji

Glavni autori:	Matthew J Strauss, Katherine D Porter, Pamela M Quizon, Sarah E Davis, Steven Lin, Yaxia Yuan, Gustavo A Martinez-Muniz, Wei-Lun Sun, Chang-Guo Zhan, Jun Zhu
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2022-01-01
Serija:	PLoS ONE
Online pristup:	https://doi.org/10.1371/journal.pone.0275182
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