Genetic Ablation of Pyruvate Dehydrogenase Kinase Isoform 4 Gene Enhances Recovery from Hyperoxic Lung Injury: Insights into Antioxidant and Inflammatory Mechanisms

Background: Pyruvate dehydrogenase kinase isoform 4 (PDK4) plays a pivotal role in the regulation of cellular proliferation and apoptosis. The objective of this study was to examine whether the genetic depletion of the PDK4 gene attenuates hyperoxia-induced lung injury in neonatal mice. Methods: Neo...

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Principais autores:	Keisuke Watanabe, Akie Kato, Hiroyuki Adachi, Atsuko Noguchi, Hirokazu Arai, Masato Ito, Fumihiko Namba, Tsutomu Takahashi
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2024-03-01
Series:	Biomedicines
Assuntos:	bronchopulmonary dysplasia pyruvate dehydrogenase kinase isoform 4 hyperoxia
Acceso en liña:	https://www.mdpi.com/2227-9059/12/4/746
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