Nitidine chloride inhibits colorectal cancer by targeting BUB1: mechanistic insights from molecular dynamics simulation, spatial transcriptomics, and single-cell RNA sequencing

Abstract Background Colorectal cancer (CRC) is a prevalent malignancy with the efficacy of current treatments limited. Nitidine chloride (NC), a natural alkaloid, exhibits antitumor potential, but its mechanism in CRC remains unclear. Objective To investigate the antitumor effects and mechanisms of...

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Hauptverfasser:	Ke-Jun Wu, Jin-Cheng Li, Li-Min Liu, Xiao-Jue Huang, Liu-Hui Mo, Jing-Wen Ling, Kun-Hua Xiong, Wei Zhang, Rong-Quan He, Hui Li, Gang Chen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-11-01
Schriftenreihe:	BMC Gastroenterology
Schlagworte:	Colorectal cancer Nitidine chloride RAD21–BUB1 axis Spatial transcriptomics Single-cell sequencing Immune microenvironment
Online-Zugang:	https://doi.org/10.1186/s12876-025-04423-8
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