TRPM2 enhances ischemic excitotoxicity by associating with PKCγ

Summary: N-methyl-D-aspartate receptor (NMDAR)-mediated glutamate excitotoxicity significantly contributes to ischemic neuronal death and post-recanalization infarction expansion. Despite tremendous efforts, targeting NMDARs has proven unsuccessful in clinical trials for mitigating brain injury. Her...

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Principais autores:	Pengyu Zong, Jianlin Feng, Nicholas Legere, Yunfeng Li, Zhichao Yue, Cindy X. Li, Yasuo Mori, Barbara Miller, Bing Hao, Lixia Yue
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2024-02-01
Serija:	Cell Reports
Teme:	CP: Neuroscience CP: Molecular biology
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2211124724000500
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