Airway epithelial stem cell renewal and differentiation: overcoming challenging steps towards clinical-grade tissue engineering

Abstract Background Despite their life-saving potential, tissue engineering approaches for the treatment of extensive tracheal and bronchial defects still face significant limitations. A major challenge is the inability to regenerate a functional airway epithelium containing the appropriate amount o...

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Principais autores:	Davide Adamo, Vincenzo Giuseppe Genna, Giulia Galaverni, Chiara Chiavelli, Alessia Merra, Fabio Lepore, Federica Boraldi, Daniela Quaglino, Jessica Evangelista, Filippo Lococo, Graziella Pellegrini
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-07-01
Series:	Stem Cell Research & Therapy
Assuntos:	Tracheobronchial epithelium Epithelial stem cells Airway holoclones Regenerative medicine Tissue engineering Airway reconstruction
Acceso en liña:	https://doi.org/10.1186/s13287-025-04478-0
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