Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition

Abstract Aurora B kinase (AURKB) inhibitors have been trialled in a range of different tumour types but are not approved for any indication. Expression of the human papilloma virus (HPV) oncogenes and loss of retinoblastoma (RB) protein function has been reported to increase sensitivity to AURKB inh...

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Egile Nagusiak:	Shivam Vora, Ariel Andrew, Ramyashree Prasanna Kumar, Deborah Nazareth, Alexis Bonfim-Melo, Yoon Lim, Xin Yee Ong, Madushan Fernando, Yaowu He, John D. Hooper, Nigel AJ McMillan, Jelena Urosevic, Jon Travers, Jamal Saeh, Sharad Kumar, Mathew JK Jones, Brian Gabrielli
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Publishing Group 2024-11-01
Saila:	Cell Death and Disease
Sarrera elektronikoa:	https://doi.org/10.1038/s41419-024-07204-5
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