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Herpes simplex virus 1 envelope glycoprotein C shields glycoprotein D to protect virions from entry-blocking antibodies

ABSTRACT Herpes simplex virus 1 (HSV-1) gD interaction with the host cell receptor nectin-1 triggers the membrane fusion cascade during viral entry. Potent neutralizing antibodies to gD prevent receptor-binding or prevent gD interaction with gH/gL critical for fusion. HSV has many strategies to evad...

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Main Authors: McKenna A. Hull, Suzanne M. Pritchard, Anthony V. Nicola
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2025-04-01
Series:Journal of Virology
Subjects:
herpes simplex virus
viral glycoproteins
glycoprotein C
glycoprotein D
receptor binding
antibodies
Online Access:https://journals.asm.org/doi/10.1128/jvi.00090-25
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