Integrated single-cell and spatial transcriptomics reveal divergent immunological and stromal programs in peritoneal versus ovarian endometriosis

Abstract Background Endometriosis encompasses heterogeneous lesions, primarily peritoneal and ovarian subtypes, with distinct immunological and fibrotic features. The subtype-specific roles of the immune microenvironment in pathogenesis remain unclear. Integrated analysis combining high-resolution c...

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Hauptverfasser:	Fangjie He, Shuiling Zu, Yan Lin, Jun Shi, Shunhe Lin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-04-01
Schriftenreihe:	BMC Women's Health
Schlagworte:	Endometriosis Single-cell RNA sequencing Spatial transcriptomics Immune-hot niche Immune-cold niche CCL19-CCR7 axis
Online-Zugang:	https://doi.org/10.1186/s12905-026-04456-5
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