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Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer

Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by profound metabolic rewiring and a strongly immunosuppressive tumor microenvironment, both of which contribute to poor therapeutic responses. Immunogenic cell death (ICD) represents a potential strategy to overcome immune suppressio...

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Principais autores: Nneka E. Mbah, Damien Sutton, Hanna S. Hong, Rashi Singhal, Rosa E. Menjivar, Matthew D. Perricone, Heather Giza, Peter Sajjakulnukit, Amy L. Myers, Zeribe C. Nwosu, Jonathan M. Alektiar, Jason Lin, Daniel Long, Anthony C. Andren, Li Zhang, Howard C. Crawford, Timothy L. Frankel, Marina Pasca di Magliano, Luigi Franchi, Yatrik M. Shah, Costas A. Lyssiotis
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:Cancer & Metabolism
Online adgang:https://doi.org/10.1186/s40170-026-00428-3
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