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AZD9291 Resistance Reversal Activity of a pH‐Sensitive Nanocarrier Dual‐Loaded with Chloroquine and FGFR1 Inhibitor in NSCLC

Abstract AZD9291 can effectively prolong survival of non‐small cell lung cancer (NSCLC) patients. Unfortunately, the mechanism of its acquired drug resistance is largely unknown. This study shows that autophagy and fibroblast growth factor receptor 1 signaling pathways are both activated in AZD9291...

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Autori principali: Yu Gu, Songtao Lai, Yang Dong, Hao Fu, Liwei Song, Tianxiang Chen, Yourong Duan, Zhen Zhang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2021-01-01
Serie:Advanced Science
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Accesso online:https://doi.org/10.1002/advs.202002922
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