A comprehensive evaluation of a novel targeted-sequencing workflow for Mycobacterium species identification and anti-tuberculosis drug-resistance detection

BackgroundAlthough several World Health Organization–endorsed targeted next-generation sequencing (tNGS) assays exist for tuberculosis (TB) drug-resistance detection, their target selection and diagnostic accuracy vary widely. In this study, we developed a novel tNGS workflow (the TB Pro assay) and...

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Detalhes bibliográficos

Principais autores:	Xichao Ou, Shaojun Pei, Hongru Li, Zhonghua Qin, Richard Anthony, Jichun Wang, Zexuan Song, Ruida Xing, Lixia Zhang, Chong Teng, Hui Xia, Yang Zhou, Yuanyuan Song, Yang Zheng, Shengfen Wang, Bing Zhao, Yanlin Zhao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-06-01
coleção:	Frontiers in Cellular and Infection Microbiology
Assuntos:	Mycobacterium tuberculosis non-tuberculous mycobacteriosis drug resistance multiplex PCR (polymerase chain reaction) targeted next generation sequencing (tNGS)
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcimb.2025.1584237/full
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