A multi-epitope pan-betacoronavirus vaccine construct predicted to induce broad-spectrum and durable immune responses: an immunoinformatics approach

IntroductionRecurrent zoonotic spillovers and continuous antigenic evolution among betacoronaviruses, including SARS-CoV, MERS-CoV, and SARS-CoV-2, highlight the urgent need for a broad-spectrum vaccine capable of eliciting cross-protective immunity. Conventional vaccines, although effective against...

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Autori principali:	Anabella Margareth Arapa, Trina Ekawati Tallei, Rinaldi Idroes, Fatimawali, Elly Juliana Suoth, Maghfirah Savitri, Ahmad Akroman Adam, Beivy Jonathan Kolondam, Chika Yamada, Rosy Iara Maciel de Azambuja Ribeiro, Amama Rani, Moon Nyeo Park, Youdiil Ophinni, Bonglee Kim
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-03-01
Serie:	Frontiers in Bioinformatics
Soggetti:	conserved epitopes immune simulation immunoinformatics multi-epitope peptide vaccine pan-betacoronavirus receptor-binding domain (RBD)
Accesso online:	https://www.frontiersin.org/articles/10.3389/fbinf.2026.1784011/full
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