Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches

The complement system is associated with various diseases such as inflammation or auto-immune diseases. Complement-targeted drugs could provide novel therapeutic intervention against the above diseases. C1s, a serine protease, plays an important role in the CS and could be an attractive target since...

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Hlavní autoři:	Katalin Szilágyi, István Hajdú, Beáta Flachner, Zsolt Lőrincz, Júlia Balczer, Péter Gál, Péter Závodszky, Chiara Pirli, Balázs Balogh, István M. Mándity, Sándor Cseh, György Dormán
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2019-10-01
Edice:	Molecules
Témata:	complement system virtual screening c1s inhibitor factorxa biological screening pharmacophore modelling
On-line přístup:	https://www.mdpi.com/1420-3049/24/20/3641
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