Polymorphisms in mTOR and Calcineurin Signaling Pathways Are Associated With Long-Term Clinical Outcomes in Kidney Transplant Recipients

Monitoring of immunosuppressive drugs, such as calcineurin and mTOR inhibitors, is essential to avoid undesirable kidney transplant outcomes. Polymorphisms in pharmacokinetics-related genes have been associated with variability in blood levels of immunosuppressive drugs and adverse effects, but infl...

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Autori principali:	Antony Brayan Campos-Salazar, Fabiana Dalla Vecchia Genvigir, Claudia Rosso Felipe, Helio Tedesco-Silva, José Medina-Pestana, Gabriela Vieira Monteiro, Rodrigo de Gouveia Basso, Alvaro Cerda, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2018-11-01
Serie:	Frontiers in Pharmacology
Soggetti:	kidney transplant immunosuppressive drugs mTOR calcineurin FOXP3 pharmacogenetics
Accesso online:	https://www.frontiersin.org/article/10.3389/fphar.2018.01296/full
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