Reovirus FAST Protein Enhances Vesicular Stomatitis Virus Oncolytic Virotherapy in Primary and Metastatic Tumor Models

The reovirus fusion-associated small transmembrane (FAST) proteins are the smallest known viral fusogens (∼100–150 amino acids) and efficiently induce cell-cell fusion and syncytium formation in multiple cell types. Syncytium formation enhances cell-cell virus transmission and may also induce immuno...

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Bibliographic Details

Main Authors:	Fabrice Le Boeuf, Simon Gebremeskel, Nichole McMullen, Han He, Anna L. Greenshields, David W. Hoskin, John C. Bell, Brent Johnston, Chungen Pan, Roy Duncan
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2017-09-01
Series:	Molecular Therapy: Oncolytics
Subjects:	oncolytic virotherapy vesicular stomatitis virus FAST protein syncytium formation 4T1 mammary adenocarcinoma CT26 colon carcinoma
Online Access:	http://www.sciencedirect.com/science/article/pii/S237277051730030X
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