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GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma

Abstract Background G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3 (GRK3) is critical for GPCR signaling. Our genomic analysis showed that GRK3 expression correlated with poor prognosis of gastric adenocarcinoma (GAC) patients. However,...

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Principais autores: Yuan Li, Yibo Fan, Jinbang Xu, Longfei Huo, Ailing W. Scott, Jiankang Jin, Boxuan Yang, Shan Shao, Lang Ma, Ying Wang, Xiaodan Yao, Melissa Pool Pizzi, Matheus Sewastjanow Da Silva, Guoliang Zhang, Lijuan Zhuo, Eun Jeong Cho, Kevin N. Dalby, Namita D. Shanbhag, Zhenning Wang, Wenliang Li, Shumei Song, Jaffer A. Ajani
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-08-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
Gastric adenocarcinoma
GRK3
Hippo/YAP1
Prognosis
Peritoneal metastases
Acesso em linha:https://doi.org/10.1186/s13046-022-02463-6
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