Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors

Abstract Background Triple-negative breast cancer (TNBC) is a subtype of breast cancer with limited treatment options and poor clinical prognosis. Inhibitors of transcriptional CDKs are currently under thorough investigation for application in the treatment of multiple cancer types, including breast...

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Hlavní autoři:	Vera E. van der Noord, Wanda van der Stel, Gijs Louwerens, Danielle Verhoeven, Hendrik J. Kuiken, Cor Lieftink, Melanie Grandits, Gerhard F. Ecker, Roderick L. Beijersbergen, Peter Bouwman, Sylvia E. Le Dévédec, Bob van de Water
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-05-01
Edice:	Breast Cancer Research
Témata:	Triple-negative breast cancer Transcriptional cyclin-dependent kinases CDK12/13 THZ531 ABCG2 Drug resistance
On-line přístup:	https://doi.org/10.1186/s13058-023-01648-x
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