Phosphoantigen sensing combines TCR-dependent recognition of the BTN3A IgV domain and germline interaction with BTN2A1

Summary: Vγ9Vδ2 T cells play critical roles in microbial immunity by detecting target cells exposed to pathogen-derived phosphoantigens (P-Ags). Target cell expression of BTN3A1, the “P-Ag sensor,” and BTN2A1, a direct ligand for T cell receptor (TCR) Vγ9, is essential for this process; however, the...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Carrie R. Willcox, Mahboob Salim, Charlotte R. Begley, Mohindar M. Karunakaran, Emily J. Easton, Carlotta von Klopotek, Katie A. Berwick, Thomas Herrmann, Fiyaz Mohammed, Mark Jeeves, Benjamin E. Willcox
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-04-01
Schriftenreihe:	Cell Reports
Schlagworte:	CP: Immunology
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124723003327
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