Preparation of Antiproliferative Terpene-Alkaloid Hybrids by Free Radical-Mediated Modification of <i>ent</i>-Kauranic Derivatives

A convenient strategy for molecular editing of available <i>ent</i>-kauranic natural scaffolds has been developed based on radical mediated C–C bond formation. Iodine atom transfer radical addition (ATRA) followed by rapid ionic elimination and radical azidoalkylation were investigated. Both reactio...

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Главные авторы:	Elena Pruteanu, Vladilena Gîrbu, Nicon Ungur, Leentje Persoons, Dirk Daelemans, Philippe Renaud, Veaceslav Kulcițki
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2021-07-01
Серии:	Molecules
Предметы:	diterpene <i>ent</i>-kaurane alkaloids radical chemistry ATRA lactam
Online-ссылка:	https://www.mdpi.com/1420-3049/26/15/4549
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