Safety and efficacy of combined B-cell depleting therapy and daratumumab in patients with autoimmune encephalitis (RADIA): study protocol for a multicenter, randomized trial

BackgroundAnti-NMDA receptor encephalitis (NMDARE) is the most common autoimmune encephalitis, involving an immune response against NMDA receptors on neurons. Despite standard immunotherapy, approximately 30% of critically ill patients require long-term intensive care. Current management strategies...

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Autors principals:	Wei Xie, Lin-Jie Zhang, Chunxian Yue, Baojie Wang, Shougang Guo, Xuegan Lian, Chao Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-05-01
Col·lecció:	Frontiers in Neurology
Matèries:	autoimmune encephalitis daratumumab mRS NMDA receptors plasma cells
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fneur.2026.1783651/full
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