Pan-tumor validation of FoundationOne®CDx as a companion diagnostic for RET fusions as a predictor of response to selpercatinib

BackgroundRET fusions represent a subgroup of alterations in cancer biology that exhibit sensitivity to selective RET kinase inhibitors. We analytically validated a next-generation sequencing-based companion diagnostic (CDx) to detect RET fusions in solid tumors via a comprehensive genomic profiling...

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Bibliografiska uppgifter

Huvudupphov:	Allison van den Hout, Richard S. P. Huang, Caleb Ho, David L. Smith, Douglas A. Mata, Baljinder Kaur, Sameera R. Wijayawardana, Jennifer Wright, Anna M. Szpurka, Douglas I. Lin
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2026-05-01
Serie:	Frontiers in Oncology
Ämnen:	companion diagnostic (CDx) comprehensive genomic profiling (CGP) FoundationOne®CDx RET fusion validation
Länkar:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1820286/full
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