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Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents

The ADP-ribosyl hydrolases PARG and ARH3 counteract PARP enzymatic activity by removing ADP-ribosylation. PARG and ARH3 activities have a synthetic lethal effect; however, the specific molecular mechanisms underlying this response remain unknown. Here, we show that the PARG and ARH3 synthetic lethal...

Deskribapen osoa

Gorde:
Egile Nagusiak: Rocco Caggiano, Evgeniia Prokhorova, Lena Duma, Kira Schützenhofer, Raffaella Lauro, Giuliana Catara, Rosa Marina Melillo, Angela Celetti, Rebecca Smith, S John Weroha, Scott H Kaufmann, Ivan Ahel, Luca Palazzo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2025-01-01
Saila:Neoplasia: An International Journal for Oncology Research
Gaiak:
DNA damage
ADP-ribosylation
ADP-ribosyl hydrolases
ARH3
PARG inhibitor
Alkylating drugs
Sarrera elektronikoa:http://www.sciencedirect.com/science/article/pii/S1476558624001337
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