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Integrating Network Pharmacology, Molecular Docking, and Experimental Validation: Andrographolide Attenuates Acute Liver Injury via the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway

Background/Objectives: Andrographolide (Andro), a natural diterpenoid lactone, possesses a wide range of pharmacological properties, including notable anti-inflammatory, antioxidant, antitumor, and immunomodulatory activities. Despite its acknowledged therapeutic promise, the exact protective mechan...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Yankun Zhang, Shuanghui Liu, Xiaoxia Liang, Lizi Yin, Changliang He
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2025-12-01
Schriftenreihe:Biomolecules
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Online-Zugang:https://www.mdpi.com/2218-273X/15/12/1743
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