Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis

Abstract Background Early-onset familial Alzheimer’s disease (EOfAD) is promoted by dominant mutations, enabling the study of Alzheimer’s disease (AD) pathogenic mechanisms through generation of EOfAD-like mutations in animal models. In a previous study, we generated an EOfAD-like mutation, psen1 Q9...

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主要な著者:	Yang Dong, Morgan Newman, Stephen M. Pederson, Karissa Barthelson, Nhi Hin, Michael Lardelli
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2021-03-01
シリーズ:	BMC Genomics
オンライン･アクセス:	https://doi.org/10.1186/s12864-021-07509-1
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