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Analysing the Combined Effects of Radiotherapy and Chemokine Receptor 5 Antagonism: Complementary Approaches to Promote T Cell Function and Migration in Oesophageal Adenocarcinoma

The presence of an immunosuppressive tumour microenvironment in oesophageal adenocarcinoma (OAC) is a major contributor to poor responses. Novel treatment strategies are required to supplement current regimens and improve patient survival. This study examined the immunomodulatory effects that radiat...

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Principais autores: Maria Davern, Cillian O’ Donovan, Noel E. Donlon, Eimear Mylod, Caoimhe Gaughan, Anshul Bhardwaj, Andrew D. Sheppard, Dara Bracken-Clarke, Christine Butler, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Melissa J. Conroy
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-04-01
Serier:Biomedicines
Fag:
T cell recruitment
Maraviroc
cancer immune suppression
chemokines
CCR5
oesophageal adenocarcinoma
Online adgang:https://www.mdpi.com/2227-9059/12/4/819
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