Simultaneous analysis of dapagliflozin and its three related impurities by stability-indicating UPLC method and in vitro toxicity evaluation

A new stability- indicating analytical method by UPLC was developed for the simultaneous determination of dapagliflozin and three of its synthesis impurities. A Waters® Acquity UPLC H- Class model was used for method development and validation. The separation was achieved in a Zorbax phenyl column...

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Principais autores:	Lívia Bueno, Joanna Wittckind Manoel, Mariana Koetz, Amélia Teresinha Henriques, Martin Steppe, Elfrides Eva Scherman Schapoval
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Universidade Federal do Rio Grande do Sul 2023-01-01
Colecção:	Drug Analytical Research
Assuntos:	dapagliflozin, UPLC, validation, drug impurities, toxicity assay
Acesso em linha:	https://seer.ufrgs.br/index.php/produto&producao/ojs/index.php/dar/article/view/128661
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