Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy

Programmed Cell Death-1 (PD-1) is an inhibitory immune receptor, which plays critical roles in T cell co-inhibition and exhaustion upon binding to its ligands PD-L1 and PD-L2. We report the crystal structure of the human PD-1 ectodomain and the mapping of the PD-1 binding interface. Mutagenesis stud...

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ग्रंथसूची विवरण

मुख्य लेखकों:	Eszter Lázár-Molnár, Lisa Scandiuzzi, Indranil Basu, Thomas Quinn, Eliezer Sylvestre, Edith Palmieri, Udupi A. Ramagopal, Stanley G. Nathenson, Chandan Guha, Steven C. Almo
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Elsevier 2017-03-01
श्रृंखला:	EBioMedicine
विषय:	PD-1 Immunotherapy High-affinity mutant Radio-immunotherapy PD-1 Ig fusion protein
ऑनलाइन पहुंच:	http://www.sciencedirect.com/science/article/pii/S2352396417300622
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