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Anticancer activity of triterpene glycosides from the sea star Solaster pacificus

Abstract Marine triterpene glycosides are known to exhibit significant anticancer activity. We investigated pacificusoside C and cucumariosides C1 and C2 isolated from a sea star Solaster pacificus in prostate cancer models with varying drug resistance and in non-cancerous cells in vitro. Cucumarios...

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Principais autores: Sergey A. Dyshlovoy, Jessica Hauschild, Malte Kriegs, Konstantin Hoffer, Olga Y. Burenina, Nadja Strewinsky, Timofey V. Malyarenko, Alla A. Kicha, Natalia V. Ivanchina, Valentin A. Stonik, Markus Graefen, Carsten Bokemeyer, Gunhild von Amsberg
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-08-01
Serier:Scientific Reports
Fag:
Triterpene glycosides
Prostate cancer
Solaster pacificus
Marine natural compounds
P-glycoprotein
MAPK
Online adgang:https://doi.org/10.1038/s41598-025-12914-7
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