Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide

Gene knockout and knockdown strategies have been immensely successful probes of gene function, but small molecule inhibitors (SMIs) of gene products allow much greater time resolution and are particularly useful when the targets are essential for cell replication or survival. SMIs also serve as lead...

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Principais autores:	Nathan A. Snyder, Adam Kim, Louis Kester, Andrew N. Gale, Christian Studer, Dominic Hoepfner, Silvio Roggo, Stephen B. Helliwell, Kyle W. Cunningham
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2019-03-01
coleção:	G3: Genes, Genomes, Genetics
Assuntos:	auxin auxin inducible degron functional genomics glycosylation Golgi rapamycin
Acesso em linha:	http://g3journal.org/lookup/doi/10.1534/g3.118.200748
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