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Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment

N-nitrosamines and nitrosamine drug substance related impurities (NDSRIs) became a critical topic for the development and safety of small molecule medicines following the withdrawal of various pharmaceutical products from the market. To assess the mutagenic and carcinogenic potential of different N-...

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Bibliografiset tiedot
Päätekijät: Andreas H. Göller, Sandra Johanssen, Adam Zalewski, Verena Ziegler
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2024-07-01
Sarja:Frontiers in Pharmacology
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Linkit:https://www.frontiersin.org/articles/10.3389/fphar.2024.1415266/full
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