Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds

Abstract Since the advances in protein engineering and manufacture, over the last 30 years, antibody-based immunotherapeutic has become a powerful strategy to treat diseases. The T-cell engaging bispecific antibody (BsAb) by combining the Fab binding domain of tumor antigens and Fab or single-chain...

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Hlavní autoři:	Lin Yu, Nan Huang, Liangpeng Ge, Heng Sun, Yuna Fu, Chundong Liu, Jianhua Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2021-06-01
Edice:	Journal of Biological Engineering
Témata:	Bispecific antibody ScFv Disulfide bond Stability
On-line přístup:	https://doi.org/10.1186/s13036-021-00272-7
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