Vaccine-educated T cells and a CD123 bispecific T-cell engager for treatment of acute myeloid leukemia

Abstract: T-cell engager (TCE) therapy has demonstrated significant therapeutic efficacy in patients with hematologic malignancies. Durable responses have been linked with T-cell clonotypic expansion. We hypothesized that combining vaccine-educated T cells (veTcs) that induce the expansion of leukem...

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Detalhes bibliográficos

Principais autores:	Jessica Liegel, Dina Stroopinsky, Giulia Cheloni, Dimitra Karagkouni, Myrna Nahas, Yuling Ma, Daniela Torres, Isabella Saldarriaga, Shuoshuo Wang, Antonella Arruda de Amaral, Athanasios Ploumakis, John Clohessy, Joseph Abirached, Lina Bisharat, Paula Fraenkel, Ozlem Yildirim, Hélène Bonnevaux, Stephane Guerif, Katie Rallis, Georges Chedid, Donald Kufe, Ioannis S. Vlachos, David Avigan, Jacalyn Rosenblatt
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-11-01
coleção:	Blood Advances
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2473952925004938
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