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Hepatitis C virus E1 protein-specific linear B-cell epitopes, pan-genotype reactivity, and functional relevance

BackgroundHepatitis C virus (HCV) infection poses a major global risk for chronic liver disease, underscoring the critical need for prevention. Our previous studies demonstrated that HCV-modified soluble E1/E2F442NYT envelope glycoproteins delivered from an mRNA-lipid nanoparticle (LNP) vaccine plat...

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Principais autores: Babu E Preedia, Yuki Haga, Ranjit Ray
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-03-01
Serier:Frontiers in Immunology
Fag:
antibody response
B-cell epitope
E1 protein
ELISA
envelope glycoproteins
genotypes
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1745299/full
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