The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications
This review explores the critical function of the evolutionarily conserved ChaC-like enzyme family as central regulators of intracellular glutathione (GSH) homeostasis, focusing on the mammalian isoforms CHAC1 and CHAC2. We detail how these γ-glutamylcyclotransferases degrade GSH, thereby modulating...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2025-12-01
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| Schriftenreihe: | Frontiers in Molecular Biosciences |
| Schlagworte: | |
| Online-Zugang: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1724944/full |
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