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Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?

BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types. CRP exists in two structurally and functionally distinct isoforms, circulating pentameric...

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Autori principali: Anne Helene Køstner, Anniken Jørlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2023-03-01
Serie:Frontiers in Immunology
Soggetti:
systemic inflammation
C-reactive protein (CRP)
CRP isoforms
monomeric CRP
colon cancer
immunohistochemistry (IHC)
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170443/full
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