Loss of chromosome Y is unrelated to the composition of the tumor microenvironment and patient prognosis in muscle-invasive urothelial bladder cancers

Abstract Background Loss of chromosome Y (LOY) has recently been proposed to be associated with cancer aggressiveness, altered T-cell function, and poor prognosis in bladder carcinomas. Methods Chromosome Y was analyzed using fluorescence in-situ hybridization on a tissue microarray containing 2,071...

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Auteurs principaux:	Henning Plage, Viktoria Ahlburg, Sebastian Hofbauer, Kira Furlano, Sarah Weinberger, Annika Fendler, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Niclas C. Blessin, Maximilian Lennartz, Andreas H. Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Stefan Koch, Nico Adamini, Ronald Simon, Guido Sauter, Henrik Zecha, Joachim Weischenfeldt, Tobias Klatte, Sarah Minner, David Horst, Thorsten Schlomm, Martina Kluth
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-04-01
Collection:	BMC Cancer
Sujets:	Loss of chromosome Y Tissue microarray  Urothelial bladder cancer Tumor microenvironment
Accès en ligne:	https://doi.org/10.1186/s12885-025-14019-w
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