In Vitro Evaluation of Poly(D,L-lactide-co-glycolide) In Situ Gels and Pharmacokinetics Following Subcutaneous Injection in Rats for Model Drugs

<b>Background/Objectives.</b> This research supports the development of long-acting injectables (LAIs) via in situ gel (ISG) technology by illustrating the influence of drug properties and formulation variables on in vitro drug release (Part 1), and providing an example of a point-to-point in vitro–...

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Principais autores:	Sandy Van Hemelryck, Charlotte Vercammen, Eline Seldeslachts, Koen Wuyts, Ils Pijpers, René Holm, Erik Mannaert, Peter Langguth
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2026-02-01
Series:	Pharmaceutics
Assuntos:	in situ gels solubility in vitro release pharmacokinetics sustained release in vitro–in vivo correlation
Acceso en liña:	https://www.mdpi.com/1999-4923/18/2/219
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