Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brain

Abstract Background Neuropsychiatric disorders are highly complex conditions and the risk of developing a disorder has been tied to hundreds of genomic variants that alter the expression and/or RNA isoforms made by risk genes. However, how these genes contribute to disease risk and onset through alt...

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Auteurs principaux:	Ricardo De Paoli-Iseppi, Shweta S. Joshi, Josie Gleeson, Yair D. J. Prawer, Yupei You, Ria Agarwal, Anran Li, Anthea Hull, Eloise M. Whitehead, Yoonji Seo, Rhea Kujawa, Raphael Chang, Mriga Dutt, Catriona McLean, Benjamin L. Parker, Michael B. Clark
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-09-01
Collection:	Genome Biology
Sujets:	RNA Splicing Neuropsychiatric Brain Long-read Nanopore
Accès en ligne:	https://doi.org/10.1186/s13059-025-03724-1
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